Director of Research AND OPERATIONS

John J. Byrnes, M.A., Ph.D.

email: | phone: 508.983.1425

John J. Byrnes, M.A., Ph.D.

Education and training

Ph.D. in Neuroscience (Behavioral Neuropharmacology)

The Ohio State University College of Medicine

Postdoctoral Fellow, Geriatric Neuropharmacology

Department of Pharmacology, Tufts University School of Medicine

Special and Scientific Staff

Department of Psychiatry, Tufts-New England Medical Center

Clinical Fellow

Department of Psychology, Westborough State Hospital


Translational Neuroscience and Psychoeducation

About Dr. Byrnes

Dr. Byrnes is co-founder and Director of Research and Operations at MWN. A neuroscientist by training, he is interested in the brain mechanisms and treatment of traumatic brain injury (TBI), dementing illnesses, drug addiction, and psychiatric diseases. He has held positions in the pharmaceutical industry and in academia, including Head of In Vivo Pharmacology at Ore Pharmaceuticals, Inc., Research Assistant Professor of Neuroscience at Tufts University School of Medicine, Staff Scientist at Millennium Pharmaceuticals, Inc., and Scientific Advisor for Resilience Therapeutics. He has also served as Coordinator of the Cognitive Rehabilitation Program at Worcester/Westborough State Hospitals (Massachusetts Department of Mental Health), and Mental Health/Academic Adjustment Counselor at the Cummings School of Veterinary Medicine at Tufts University. Currently, he is a Research Associate Professor in the Department of Biomedical Sciences at Tufts University (Grafton Campus), a Faculty Fellow at the Tufts Center for Animals and Public Policy, and a volunteer mental health service provider for Remote Area Medical ( Dr. Byrnes is a journal and book reviewer, author of numerous peer-reviewed scientific publications, and a member of the Society for Neuroscience and the International Behavioral Neuroscience Society. He holds a Doctoral degree in Neuroscience and a Master’s degree in Counseling Psychology. At MWN, Dr. Byrnes oversees research collaborations and training. Clinically, he offers individual and family-focused neuroscience consultation for cognitive impairment, and provides research expertise for cases involving complex brain-behavior relationships.

Selected Papers and Publications

Byrnes, JJ, Mann PE, Berman B, Warner A (2014). "Mental Health Risk Assessment and Action Proposal." A blueprint for a comprehensive health and wellness plan for students of Cummings School of Veterinary Medicine at Tufts University (Cummings Support Center).

Ravenelle R, Byrnes EM, Byrnes, JJ, McInni C, Park JH, Donaldson, ST (2014). Housing environment modulates physiological and behavioral responses to anxiogenic stimuli in train anxiety in rats, Neuroscience. 270:76-87.

Byrnes, JJ, Johnson, NL, Carini, LM, Byrnes, EM. (2013). Multigenerational Effects of Adolescent Morphine Exposure on Dopamine D2 Receptor Function. Psychopharmacology, 227(2):263-72.

Byrnes, JJ, Johnson, NL, Schenk, ME, Byrnes, EM. (2012). Cannabinoid Exposure in Adolescent Female Rats Induces Transgenerational Effects on Morphine Conditioned Place Preference in Male Offspring. Journal of Psychopharmacol. 26:1348-54.

Byrnes, JJ., Babb, JA., Scanlan, VF., Byrnes, EM. (2011). Adolescent opioid exposure in female rats: Transgenerational effects on morphine analgesia and anxiety-like behavior in adult offspring. Behavioural Brain Research. 218:200-205.

Byrnes, JJ, Draper, JT, Byrnes, EM (2010). Estrogen-Dopamine Interactions in Forebrain Modulation of the Sensorimotor Gating. In: Biogenic Amines: Pharmacological, Neurochemical and Molecular Aspects in the CNS, Nova Scientific Publishing.

Byrnes, J.J., Pantke, M.M., Onton, J., and Hammer, R.P. (2000). Inhibition of nitric oxide synthase in the ventral tegmental area attenuates cocaine sensitization in rats. Prog. Neuro- psychopharmacol. & Biol. Psychiatry., 24, 261-273.

Byrnes, J.J., Miller, L.G., Perkins, K., Greenblatt, D.J., and Shader, R.I. (1993). Chronic benzodiazepine administration. XI. Concurrent administration of PK11195 attenuates lorazepam discontinuation effects. Neuropsychopharmacol.,8, 267-273.

Byrnes, J.J., Pritchard, G.A., Koff, Jonathan M., and Miller, L.G. (1993). Prenatal cocaine exposure: Decreased sensitization to cocaine and decreased striatal dopamine transporter binding in offspring., Neuropharmacol., 32, 721-723.

Byrnes, J.J., Greenblatt, D.J., and Miller, L.G. (1992). Benzodiazepine receptor binding of non-benzodiazepines in vivo: Alpidem, zolpidem, and zopiclone. Brain Res. Bull., 29, 905-908.

Miller, L.G., Galpern, W.R., Byrnes, J.J., and Greenblatt, D.J., (1992). Benzodiazepine receptor binding of benzodiazepine hypnotics: Receptor and ligand specificity. Pharmacol. Biochem. Behav., 43, 413-416.

Byrnes, J J., Yang, D., Geddes, B., Ona, V., Chang, B., Goodearl, A., Zheng, G., Barnes, G., DiStefano, P., Willis, K., and McGonigle, P. (2001, November) Rodent Studies of a Novel Gene Implicated in Bipolar Disorder: Approaches Toward In Vivo Validation., Paper presented at the meeting of the Society for Neuroscience, San Diego, CA

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