John J. Byrnes, M.A., Ph.D.
Director Of Research and Operations

John J. Byrnes, M.A., Ph.D.
Specialty: Translational Neuroscience and Psychoeducation

Dr. Byrnes is co-founder and Director of Research and Operations at MWN. As a neuroscientist, he is interested in the brain mechanisms of psychiatric and neurological diseases. He has held positions in the pharmaceutical industry and in academia, including Head of In Vivo Pharmacology at Ore Pharmaceuticals, Inc., Research Assistant Professor of Neuroscience at Tufts University School of Medicine, Staff Scientist at Millennium Pharmaceuticals, Inc., and Scientific Advisor for Resilience Therapeutics. He has also served as Coordinator of the Cognitive Rehabilitation Program at Worcester/Westborough State Hospitals (Massachusetts Department of Mental Health), and Mental Health/Academic Adjustment Counselor at the Cummings School of Veterinary Medicine at Tufts University. Currently, he is an Adjunct Research Associate Professor in the Department of Biomedical Sciences at Tufts University (Cummings School), and a medical service CORE volunteer for Remote Area Medical.

Dr. Byrnes is the author of peer-reviewed scientific publications, and a member of the International Behavioral Neuroscience Society. He holds a Doctoral degree in Neuroscience and a Master’s degree in Counseling Psychology. At MWN, Dr. Byrnes oversees research collaborations and training. Clinically, he offers individual and family-focused psychoeducation for psychiatric diseases and cognitive impairment.

Education & Training

Ph.D. in Neuroscience
The Ohio State University College of Medicine

Postdoctoral Fellow - Geriatric Neuropharmacology
Department of Pharmacology
Tufts University School of Medicine

Special and Scientific Staff, Department of Psychiatry
Tufts New England Medical Center

Clinical Fellow
Department of Psychology
Westborough State Hospital

Selected Papers & Publications

Byrnes, JJ, Mann PE, Berman B, Warner A (2014). Mental Health Risk Assessment and Action Proposal."
A blueprint for a comprehensive health and wellness plan for students of Cummings School of
Veterinary Medicine at Tufts University (Cummings Support Center).

Ravenelle R, Byrnes EM, Byrnes, JJ, McInni C, Park JH, Donaldson, ST (2014). Housing environment
modulates physiological and behavioral responses to anxiogenic stimuli in train anxiety in rats,
Neuroscience. 270:76-87.

Byrnes, JJ, Johnson, NL, Carini, LM, Byrnes, EM. (2013). Multigenerational Effects of Adolescent
Morphine Exposure on Dopamine D2 Receptor Function. Psychopharmacology, 227(2):263-72.

Byrnes, JJ, Johnson, NL, Schenk, ME, Byrnes, EM. (2012). Cannabinoid Exposure in Adolescent Female
Rats Induces Transgenerational Effects on Morphine Conditioned Place Preference in Male Offspring.
Journal of Psychopharmacol. 26:1348-54.

Byrnes, JJ., Babb, JA., Scanlan, VF., Byrnes, EM. (2011). Adolescent opioid exposure in female rats:
Transgenerational effects on morphine analgesia and anxiety-like behavior in adult offspring.
Behavioural Brain Research. 218:200-205.

Byrnes, JJ, Draper, JT, Byrnes, EM (2010). Estrogen-Dopamine Interactions in Forebrain Modulation of
the Sensorimotor Gating. In: Biogenic Amines: Pharmacological, Neurochemical and Molecular Aspects
in the CNS, Nova Scientific Publishing.

Byrnes, J.J., Pantke, M.M., Onton, J., and Hammer, R.P. (2000). Inhibition of nitric oxide synthase in the
ventral tegmental area attenuates cocaine sensitization in rats. Prog. Neuro- psychopharmacol. & Biol.
Psychiatry., 24, 261-273.

Byrnes, J.J., Miller, L.G., Perkins, K., Greenblatt, D.J., and Shader, R.I. (1993). Chronic benzodiazepine
administration. XI. Concurrent administration of PK11195 attenuates lorazepam discontinuation effects.
Neuropsychopharmacol.,8, 267-273.

Byrnes, J.J., Pritchard, G.A., Koff, Jonathan M., and Miller, L.G. (1993). Prenatal cocaine exposure:
Decreased sensitization to cocaine and decreased striatal dopamine transporter binding in offspring.,
Neuropharmacol., 32, 721-723.

Byrnes, J.J., Greenblatt, D.J., and Miller, L.G. (1992). Benzodiazepine receptor binding of non-
benzodiazepines in vivo: Alpidem, zolpidem, and zopiclone. Brain Res. Bull., 29, 905-908.

Miller, L.G., Galpern, W.R., Byrnes, J.J., and Greenblatt, D.J., (1992). Benzodiazepine receptor binding of
benzodiazepine hypnotics: Receptor and ligand specificity. Pharmacol. Biochem. Behav., 43, 413-416.

Byrnes, J J., Yang, D., Geddes, B., Ona, V., Chang, B., Goodearl, A., Zheng, G., Barnes, G., DiStefano, P.,
Willis, K., and McGonigle, P. (2001, November) Rodent Studies of a Novel Gene Implicated in Bipolar
Disorder: Approaches Toward In Vivo Validation., Paper presented at the meeting of the Society for
Neuroscience, San Diego, CA

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